Monocyte Chemotactic Protein 5 (MCP5)

CCL12; SCYA12; Chemokine C-C-Motif Ligand 12; MCP-1-related chemokine; Monocyte chemoattractant protein 5; Small-inducible cytokine A12

SPN	U769
MGI	108224
PubMed	16585273
UniProt	Q62401
Wiki	CCL12

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family . It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine.

CCL12 specifically attracts eosinophils, monocytes and lymphocytes.This chemokine is found predominately in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.

It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on chromosome 11.

Reference

"Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation."
J. Exp. Med. 184:1939-1951(1996) [PubMed] [Europe PMC] [Abstract]

"Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1."
J. Exp. Med. 185:99-109(1997) [PubMed] [Europe PMC] [Abstract]

"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]