Laminin Alpha 4 (LAMa4)
LAM-A4; LAMA3
Laminin subunit alpha-4 isalpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Also, alternative splicing involving the first intron in the 5' UTR, and laminin alpha 4 like isoforms have been noted, however, the full-length nature of these products is not known.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Hu01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Hu01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Hu01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Hu01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Hu01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Mu01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Mu01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Mu01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Mu01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Mu01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Ra01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Ra01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Ra01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Ra01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Ra01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Ca01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Ca01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Ca01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Ca01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Ca01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Po01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Po01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Po01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Po01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Po01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Bo01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Bo01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Bo01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Bo01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Bo01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Rb01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Rb01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Rb01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Rb01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Rb01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU767Mo01 | Recombinant Laminin Alpha 4 (LAMa4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU767Mo01 | Monoclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IP. |
| PAU767Mo01 | Polyclonal Antibody to Laminin Alpha 4 (LAMa4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU767Mo01 | CLIA Kit for Laminin Alpha 4 (LAMa4) | CLIA assay for Antigen Detection |
| ELU767Mo01 | ELISA Kit for Laminin Alpha 4 (LAMa4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure and expression of a novel human laminin alpha 4 chain."
FEBS Lett. 365:183-188(1995) [PubMed] [Europe PMC] [Abstract]
"The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains."
Eur. J. Biochem. 238:813-821(1996) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The structural organisation of LAMA4, the gene encoding laminin alpha4."
Eur. J. Biochem. 248:15-23(1997) [PubMed] [Europe PMC] [Abstract]
"Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain."
Genomics 22:237-239(1994) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells."
Circulation 116:515-525(2007) [PubMed] [Europe PMC] [Abstract]