Laminin Gamma 2 (LAMC2)
B2T; EBR2; EBR2A; LAMB2T; LAMNB2; Kalinin/nicein/epiligrin 100 kDa subunit; Cell-scattering factor 140 kDa subunit; Ladsin 140 kDa; Large adhesive scatter factor 140 kDa
LAMC2 is the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5, which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Hu01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Hu01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Hu01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Hu01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Hu01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Mu01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Mu01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Mu01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Mu01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Mu01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Ra01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Ra01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Ra01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Ra01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Ra01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Ca01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Ca01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Ca01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Ca01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Ca01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Po01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Po01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Po01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Po01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Po01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Bo01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Bo01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Bo01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Bo01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Bo01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Rb01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Rb01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Rb01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Rb01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Rb01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU761Mo01 | Recombinant Laminin Gamma 2 (LAMC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU761Mo01 | Monoclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IP. |
| PAU761Mo01 | Polyclonal Antibody to Laminin Gamma 2 (LAMC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU761Mo01 | CLIA Kit for Laminin Gamma 2 (LAMC2) | CLIA assay for Antigen Detection |
| ELU761Mo01 | ELISA Kit for Laminin Gamma 2 (LAMC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment."
J. Cell Biol. 119:679-693(1992) [PubMed] [Europe PMC] [Abstract]
"The 100-kDa chain of nicein/kalinin is a laminin B2 chain variant."
Eur. J. Biochem. 219:209-218(1994) [PubMed] [Europe PMC] [Abstract]
"Structure of the human laminin gamma 2 chain gene (LAMC2): alternative splicing with different tissue distribution of two transcripts."
Genomics 32:54-64(1996) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A large cell-adhesive scatter factor secreted by human gastric carcinoma cells."
Proc. Natl. Acad. Sci. U.S.A. 90:11767-11771(1993) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]