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Integrin Alpha 8 (ITGa8)
Integrin Alpha 8 (ITGa8)
ITG-A8
Mechanosensory hair cells within the neuroepithelia of the cochlea and vestibule have stereocilia that are indispensable for mechanosensation. Evans and Muller (2000) demonstrated that integrin alpha-8/beta-1, its ligand fibronectin, and the integrin-regulated focal adhesion kinase colocalize to the apical hair cell surface where stereocilia are forming.
In mice homozygous for a targeted mutation of integrin alpha-8, the colocalization is perturbed, and hair cells in the utricle, a vestibular subcompartment, lack stereocilia or contain malformed stereocilia. Most integrin alpha-8/beta-1-deficient mice die soon after birth due to kidney defects. Many of the surviving mice have difficulty balancing, consistent with the structural defects of the inner ear.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
U750Hu01
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
PU750Hu01
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Integrin Alpha 8 (ITGa8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Integrin Alpha 8 (ITGa8) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Integrin Alpha 8 (ITGa8) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Integrin Alpha 8 (ITGa8) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Integrin Alpha 8 (ITGa8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Integrin Alpha 8 (ITGa8) CLIA assay for Antigen Detection
Reference
"The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells." PubMed ] [Europe PMC ] [Abstract ]
"Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis." Kidney Int. 56:1468-1480(1999) [PubMed ] [Europe PMC ] [Abstract ]
"Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1." J. Cell Sci. 115:4641-4648(2002) [PubMed ] [Europe PMC ] [Abstract ]
"Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway." Biochem. Biophys. Res. Commun. 329:305-311(2005) [PubMed ] [Europe PMC ] [Abstract ]
"Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans." Am. J. Hum. Genet. 94:288-294(2014) [PubMed ] [Europe PMC ] [Abstract ]
"Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)." Matrix Biol. 23:487-496(2004) [PubMed ] [Europe PMC ] [Abstract ]
