Integrin Alpha 11 (ITGa11)

ITG-A11

SPN	U747
HGNC	6136
MGI	2442114
PubMed	12392762
RGD	1311711
UniProt	Q9UKX5
Wiki	ITGA11

Integrin alpha-11 is an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form.

Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.

Reference

"Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)."
Genomics 60:179-187(1999) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues."
J. Biol. Chem. 274:25735-25742(1999) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]