Integrin Beta 6 (ITGb6)

ITG-B6

SPN	U745
HGNC	6161
MGI	96615
PubMed	24305999
RGD	1303119
UniProt	P18564
Wiki	ITGB6

Integrins are cell-surface adhesion receptors that bind to extracellular matrices (ECM) and mediate cell-ECM interactions. Some integrins are known to play critical roles in dental enamel formation. ITGB6 expression was strongest in the maturation stage and its localization was associated with ameloblast modulation.Since the protein was clearly distinct from previously described integrins numbered beta-1 through beta-5, they designated the new protein beta-6. Krissansen et al. (1992) assigned the gene encoding the beta-6 subunit of integrin to chromosome 2 by analysis of somatic cell hybrids with a fragment of a genomic clone. They commented on the possible significance of the fact that the gene for vitronectin receptor, alpha subunit (VNRA) also maps to chromosome 2.

Reference

"Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction."
J. Biol. Chem. 265:11502-11507(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
Int. Immunol. 4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]

"Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells."
Virology 239:71-77(1997) [PubMed] [Europe PMC] [Abstract]

"The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus."
J. Virol. 74:4949-4956(2000) [PubMed] [Europe PMC] [Abstract]

"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]

"Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9."
J. Virol. 78:6967-6973(2004) [PubMed] [Europe PMC] [Abstract]

"Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins."
J. Virol. 80:9798-9810(2006) [PubMed] [Europe PMC] [Abstract]

"HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6."
Cancer Res. 67:5275-5284(2007) [PubMed] [Europe PMC] [Abstract]