Bone Morphogenetic Protein 15 (BMP15)

GDF9B; GDF9-B; ODG2; POF4; Growth/differentiation factor 9B

SPN	U737
HGNC	1068
MGI	1316745
PubMed	12044914
RGD	70990
UniProt	O95972
Wiki	BMP15

Bone morphogenetic protein 15  is a member of the TGF-beta superfamily. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.

Reference

"The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes."
Mol. Endocrinol. 12:1809-1817(1998) [PubMed] [Europe PMC] [Abstract]

"Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis."
J. Clin. Endocrinol. Metab. 84:2744-2750(1999) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the post-translational modification of recombinant human BMP-15 mature protein."
Protein Sci. 17:362-370(2008) [PubMed] [Europe PMC] [Abstract]

"The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates."
Mol. Cell. Endocrinol. 348:339-343(2012) [PubMed] [Europe PMC] [Abstract]

"Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene."
Am. J. Hum. Genet. 75:106-111(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure."
Eur. J. Endocrinol. 154:739-744(2006) [PubMed] [Europe PMC] [Abstract]

"Missense mutations in the BMP15 gene are associated with ovarian failure."
Hum. Genet. 119:408-415(2006) [PubMed] [Europe PMC] [Abstract]

"Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure."
J. Clin. Endocrinol. Metab. 91:1976-1979(2006) [PubMed] [Europe PMC] [Abstract]

"BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein."
Hum. Mutat. 30:804-810(2009) [PubMed] [Europe PMC] [Abstract]

"Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure."
Clin. Endocrinol. (Oxf.) 72:135-136(2010) [PubMed] [Europe PMC] [Abstract]