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Activin A Receptor Type I B (ACVR1B)

ACVR1-B; ACTRIB; ACVRLK4; ALK4; SKR2; Activin receptor-like kinase 4; Serine/threonine-protein kinase receptor R2

ACVR1B acts as a transducer of Activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. several truncated ACVR1B receptor isoforms are exclusively expressed in human pituitary tumors, and that the majority of such tumors did not exhibit activin-induced growth arrest in culture.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Hu01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Hu01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Hu01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Hu01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Hu01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Mu01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Mu01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Mu01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Mu01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Mu01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Ra01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Ra01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Ra01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Ra01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Ra01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Ca01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Ca01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Ca01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Ca01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Ca01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Po01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Po01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Po01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Po01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Po01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Bo01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Bo01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Bo01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Bo01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Bo01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Rb01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Rb01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Rb01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Rb01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Rb01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU729Mo01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU729Mo01 Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
PAU729Mo01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IF.
Assay Kits CLU729Mo01 CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA assay for Antigen Detection
ELU729Mo01 ELISA Kit for Activin A Receptor Type I B (ACVR1B) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas."
Biochem. Biophys. Res. Commun. 394:639-645(2010) [PubMed] [Europe PMC] [Abstract]

"Development and validation of a method for profiling post-translational modification activities using protein microarrays."
PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]

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