Activin A Receptor Type I B (ACVR1B)
ACVR1-B; ACTRIB; ACVRLK4; ALK4; SKR2; Activin receptor-like kinase 4; Serine/threonine-protein kinase receptor R2
ACVR1B acts as a transducer of Activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. several truncated ACVR1B receptor isoforms are exclusively expressed in human pituitary tumors, and that the majority of such tumors did not exhibit activin-induced growth arrest in culture.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Hu01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Hu01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Hu01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Hu01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Hu01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Mu01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Mu01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Mu01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Mu01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Mu01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Ra01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Ra01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Ra01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Ra01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Ra01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Ca01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Ca01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Ca01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Ca01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Ca01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Po01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Po01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Po01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Po01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Po01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Bo01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Bo01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Bo01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Bo01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Bo01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Rb01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Rb01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Rb01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Rb01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Rb01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU729Mo01 | Recombinant Activin A Receptor Type I B (ACVR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU729Mo01 | Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IP. |
PAU729Mo01 | Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU729Mo01 | CLIA Kit for Activin A Receptor Type I B (ACVR1B) | CLIA assay for Antigen Detection |
ELU729Mo01 | ELISA Kit for Activin A Receptor Type I B (ACVR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
Oncogene 8:2879-2887(1993) [PubMed] [Europe PMC] [Abstract]
"Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin."
Mol. Cell. Biol. 14:3810-3821(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition."
Proc. Natl. Acad. Sci. U.S.A. 91:7957-7961(1994) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Activation of signalling by the activin receptor complex."
Mol. Cell. Biol. 16:1066-1073(1996) [PubMed] [Europe PMC] [Abstract]
"Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation."
Mol. Cell. Biol. 17:1682-1691(1997) [PubMed] [Europe PMC] [Abstract]
"Roles of pathway-specific and inhibitory Smads in activin receptor signaling."
Mol. Endocrinol. 13:15-23(1999) [PubMed] [Europe PMC] [Abstract]
"Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)."
Mol. Endocrinol. 15:668-679(2001) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation regulation of the interaction between Smad7 and activin type I receptor."
FEBS Lett. 519:93-98(2002) [PubMed] [Europe PMC] [Abstract]
"Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells."
J. Clin. Endocrinol. Metab. 87:4741-4746(2002) [PubMed] [Europe PMC] [Abstract]
"Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells."
Mol. Cell. Biol. 22:2586-2597(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of the phosphotyrosine proteome from thrombin activated platelets."
Proteomics 2:642-648(2002) [PubMed] [Europe PMC] [Abstract]
"Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells."
Endocrinology 144:1603-1611(2003) [PubMed] [Europe PMC] [Abstract]
"Identification of a functional binding site for activin on the type I receptor ALK4."
J. Biol. Chem. 278:21129-21135(2003) [PubMed] [Europe PMC] [Abstract]
"FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor."
J. Mol. Endocrinol. 36:569-579(2006) [PubMed] [Europe PMC] [Abstract]
"Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination."
Development 134:4381-4393(2007) [PubMed] [Europe PMC] [Abstract]
"Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas."
Biochem. Biophys. Res. Commun. 394:639-645(2010) [PubMed] [Europe PMC] [Abstract]
"Development and validation of a method for profiling post-translational modification activities using protein microarrays."
PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
"Activation of the activin A-ALK-Smad pathway in systemic sclerosis."
J. Autoimmun. 36:181-188(2011) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]