Activin A Receptor Type II B (ACVR2B)
ACVR2-B; ActR-IIB
ACVR2B is an activin type 2 receptor. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Hu01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Hu01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Hu01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Hu01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Hu01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Mu01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Mu01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Mu01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Mu01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Mu01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Ra01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Ra01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Ra01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Ra01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Ra01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Ca01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Ca01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Ca01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Ca01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Ca01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Po01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Po01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Po01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Po01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Po01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Bo01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Bo01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Bo01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Bo01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Bo01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Rb01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Rb01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Rb01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Rb01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Rb01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU726Mo01 | Recombinant Activin A Receptor Type II B (ACVR2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU726Mo01 | Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IP. |
| PAU726Mo01 | Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU726Mo01 | CLIA Kit for Activin A Receptor Type II B (ACVR2B) | CLIA assay for Antigen Detection |
| ELU726Mo01 | ELISA Kit for Activin A Receptor Type II B (ACVR2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor."
Blood 83:2163-2170(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene."
J. Hum. Genet. 43:132-134(1998) [PubMed] [Europe PMC] [Abstract]
"Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB."
Am. J. Med. Genet. 82:70-76(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Activation of signalling by the activin receptor complex."
Mol. Cell. Biol. 16:1066-1073(1996) [PubMed] [Europe PMC] [Abstract]
"TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling."
EMBO J. 22:4465-4477(2003) [PubMed] [Europe PMC] [Abstract]
"Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."
J. Biol. Chem. 287:27313-27325(2012) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]