Mothers Against Decapentaplegic Homolog 5 (Smad5)
MADH5; Dwfc; JV5-1
SMAD5 or Mothers against decapentaplegic homolog 5 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF beta superfamily of modulators. Like many other TGF beta family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's).
The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGF beta is an inhibitor of hematopoietic progenitor cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Hu01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Hu01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Hu01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Hu01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Hu01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Mu01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Mu01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Mu01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Mu01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Mu01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Ra01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Ra01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Ra01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Ra01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Ra01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Ca01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Ca01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Ca01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Ca01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Ca01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Po01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Po01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Po01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Po01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Po01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Bo01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Bo01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Bo01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Bo01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Bo01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Rb01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Rb01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Rb01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Rb01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Rb01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU722Mo01 | Recombinant Mothers Against Decapentaplegic Homolog 5 (Smad5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU722Mo01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IP. |
| PAU722Mo01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 5 (Smad5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU722Mo01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | CLIA assay for Antigen Detection |
| ELU722Mo01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 5 (Smad5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Mad-related genes in the human."
Nat. Genet. 13:347-349(1996) [PubMed] [Europe PMC] [Abstract]
"Localization of SMAD5 and its evaluation as a candidate myeloid tumor suppressor."
Cancer Res. 57:3779-3783(1997) [PubMed] [Europe PMC] [Abstract]
"Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60."
Leukemia 11:1187-1192(1997) [PubMed] [Europe PMC] [Abstract]
"hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors."
Oncogene 16:951-956(1998) [PubMed] [Europe PMC] [Abstract]
"Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12."
J. Biol. Chem. 273:1872-1879(1998) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]