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Gremlin 1 (GREM1)
Gremlin 1 (GREM1)
PIG2; CKTSF1B1; DAND2; IHG-2; DAND2; DRM; Increased in high glucose protein 2; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1
Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway. Grem 1 inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development .
Grem 1 regulation of BMP-4 in mice embryos is essential in kidney and lung branching morphogenesis. Data from microarrays of cancer and non-cancer tissues suggest that grem1 and other BMP antagonists are important in the survival of cancer stroma survival and proliferation in some cancers. Grem 1 expression is found in many cancers and is thought to play important roles in uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma carcinomas.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
U716Mu01
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
PU716Mu01
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
LU716Mu81
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
KEU716Mu
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
U716Ra01
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
PU716Ra01
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
U716Ga01
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
PU716Ga01
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
LU716Ga71
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Gremlin 1 (GREM1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Gremlin 1 (GREM1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Gremlin 1 (GREM1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Gremlin 1 (GREM1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Gremlin 1 (GREM1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Gremlin 1 (GREM1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Gremlin 1 (GREM1) CLIA assay for Antigen Detection
Reference
"The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities." Mol. Cell 1:673-683(1998) [PubMed ] [Europe PMC ] [Abstract ]
"IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1." J. Biol. Chem. 275:9901-9904(2000) [PubMed ] [Europe PMC ] [Abstract ]
"DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain." PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Protein Sci. 13:2819-2824(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1." Nat. Genet. 44:699-703(2012) [PubMed ] [Europe PMC ] [Abstract ]
