Collagen Type XVI (COL16)

COL16A1; COL16-A1; Collagen Alpha-1(XVI)chain

SPN	U708
HGNC	2193
MGI	1095396
PubMed	10469311
RGD	1310982
UniProt	Q07092
Wiki	COL16A1

XVI collagen is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.The remaining collagens belong to the latter class with a common feature being the presence of imperfections in the gly-Xaa-Xaa repeating pattern. Within the latter class, collagens type IX, XII, and XIV form a subgroup called the FACIT collagens (for 'fibril-associated collagens with interrupted triple helices'). These collagens are associated with type I or II collagen fibrils and play a role in interaction of these fibrils with other matrix components.

Reference

"Cloning and chromosomal location of human alpha 1(XVI) collagen."
Proc. Natl. Acad. Sci. U.S.A. 89:6565-6569(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain."
Eur. J. Biochem. 228:160-168(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular structure and interaction of recombinant human type XVI collagen."
J. Mol. Biol. 339:835-853(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments."
J. Biochem. 112:856-863(1992) [PubMed] [Europe PMC] [Abstract]

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

"Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells."
Eur. J. Biochem. 242:576-584(1996) [PubMed] [Europe PMC] [Abstract]

"Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils."
Matrix Biol. 22:131-143(2003) [PubMed] [Europe PMC] [Abstract]

"Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains."
J. Biol. Chem. 281:25745-25756(2006) [PubMed] [Europe PMC] [Abstract]