Collagen Type V Alpha 2 (COL5a2)
COL5-A2; Collagen Alpha-2(V)chain; AB Collagen
Collagen alpha-2(V) chain is an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen.
This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Hu01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Hu01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Hu01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Hu01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Hu01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Mu01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Mu01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Mu01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Mu01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Mu01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Ra01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Ra01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Ra01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Ra01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Ra01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Ca01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Ca01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Ca01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Ca01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Ca01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Po01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Po01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Po01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Po01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Po01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Bo01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Bo01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Bo01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Bo01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Bo01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Rb01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Rb01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Rb01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Rb01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Rb01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU692Mo01 | Recombinant Collagen Type V Alpha 2 (COL5a2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU692Mo01 | Monoclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IP. |
| PAU692Mo01 | Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU692Mo01 | CLIA Kit for Collagen Type V Alpha 2 (COL5a2) | CLIA assay for Antigen Detection |
| ELU692Mo01 | ELISA Kit for Collagen Type V Alpha 2 (COL5a2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"Amino-terminal propeptide of human pro-alpha 2(V) collagen conforms to the structural criteria of a fibrillar procollagen molecule."
J. Biol. Chem. 264:2735-2738(1989) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the human COL3A1 and COL5A2 genes: COL5A2 has evolved differently than the other minor fibrillar collagen genes."
Matrix Biol. 20:357-366(2001) [PubMed] [Europe PMC] [Abstract]
"Homology between alpha 2(V) and alpha 1(III) collagen promoters and evidence for negatively acting elements in the alpha 2(V) first intron and 5' flanking sequences."
Gene Expr. 1:29-39(1991) [PubMed] [Europe PMC] [Abstract]
"Isolation of the alpha 3-chain of human type V collagen and characterization by partial sequencing."
Biol. Chem. Hoppe-Seyler 373:69-75(1992) [PubMed] [Europe PMC] [Abstract]
"Diversity in the processing events at the N-terminus of type-V collagen."
Eur. J. Biochem. 221:987-995(1994) [PubMed] [Europe PMC] [Abstract]
"The pro alpha 2(V) collagen gene is evolutionarily related to the major fibrillar-forming collagens."
Nucleic Acids Res. 15:181-198(1987) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Partial covalent structure of the human alpha 2 type V collagen chain."
J. Biol. Chem. 260:5533-5541(1985) [PubMed] [Europe PMC] [Abstract]
"Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2."
Proc. Natl. Acad. Sci. U.S.A. 82:3385-3389(1985) [PubMed] [Europe PMC] [Abstract]
"Complete primary structure of the human alpha 2 type V procollagen COOH-terminal propeptide."
J. Biol. Chem. 260:11216-11222(1985) [PubMed] [Europe PMC] [Abstract]
"Genetic distance of two fibrillar collagen loci, COL3A1 and COL5A2, located on the long arm of human chromosome 2."
Genomics 3:275-277(1988) [PubMed] [Europe PMC] [Abstract]
"Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce Ehlers-Danlos syndrome type I."
Hum. Mol. Genet. 7:249-255(1998) [PubMed] [Europe PMC] [Abstract]
"A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens."
J. Biol. Chem. 286:30662-30669(2011) [PubMed] [Europe PMC] [Abstract]
"A single base mutation in COL5A2 causes Ehlers-Danlos syndrome type II."
J. Med. Genet. 35:846-848(1998) [PubMed] [Europe PMC] [Abstract]
"Sequence analysis of the COL5A2 gene in patients with spontaneous cervical artery dissections."
Neurology 58:1103-1105(2002) [PubMed] [Europe PMC] [Abstract]