Collagen Type XII (COL12)

COL12-A1; COL12A1L; COL12A1; Collagen Alpha-1(XII)chain

SPN	U686
HGNC	2188
MGI	88448
PubMed	24334604
RGD	2374
UniProt	Q99715
Wiki	COL12A1

Collagen alpha-1(XII) chain is the alpha chain of type XII collagen, a member of the FACIT collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, kidney and a squamous cell carcinoma cell line. Isoform 1 is also present in the corneal epithelial Bowman's membrane (BM) and the interfibrillar matrix of the corneal stroma, but it is not detected in the limbal BM.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U686Hu01	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	MU686Hu22	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	PU686Hu01	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	KEU686Hu	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	KCU686Hu	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U686Mu01	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	PU686Mu01	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	KEU686Mu	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U686Ra01	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	MU686Ra21	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	PU686Ra01	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	KEU686Ra	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Collagen Type XII (COL12)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Collagen Type XII (COL12)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Collagen Type XII (COL12)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Collagen Type XII (COL12)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Collagen Type XII (COL12)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Collagen Type XII (COL12)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Collagen Type XII (COL12)	CLIA assay for Antigen Detection

Reference

"Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13."
Genomics 41:236-242(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The chick and human collagen alpha1(XII) gene promoter -- activity of highly conserved regions around the first exon and in the first intron."
Eur. J. Biochem. 257:362-371(1998) [PubMed] [Europe PMC] [Abstract]

"Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices."
Invest. Ophthalmol. Vis. Sci. 38:2408-2422(1997) [PubMed] [Europe PMC] [Abstract]

"The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6."
Genomics 14:225-231(1992) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]