Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 2 (GFRa2)

GDNFRB; NTNRA; RETL2; TRNR2; GDNF receptor beta; Neurturin receptor alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2

SPN	U676
HGNC	4244
MGI	1195462
PubMed	11409869
RGD	61809
UniProt	O00451
Wiki	GFRA2

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor.

This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. GDNF family receptor alpha-2 is a candidate gene for RET-associated diseases.Multiple transcript variants encoding different isoforms have been found for this gene.

Reference

"TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret."
Neuron 18:793-802(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha."
Hum. Mol. Genet. 6:1267-1273(1997) [PubMed] [Europe PMC] [Abstract]

"Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins."
Proc. Natl. Acad. Sci. U.S.A. 94:6238-6243(1997) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]