Neuregulin 2 (NRG2)

Don-1; HRG2; NTAK; Neural And Thymus Derived Activator For ErbB Kinases; Divergent Of Neuregulin-1; Pro-neuregulin-2, membrane-bound isoform

SPN	U672
HGNC	7998
MGI	1098246
PubMed	9168115
RGD	1303302
UniProt	O14511
Wiki	NRG2

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells.

The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.

Reference

"A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4."
J. Biochem. 122:675-680(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus."
Mol. Cell. Biol. 17:4007-4014(1997) [PubMed] [Europe PMC] [Abstract]

"The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q."
Hum. Genet. 104:326-332(1999) [PubMed] [Europe PMC] [Abstract]

"Ligand discrimination in signaling through an ErbB4 receptor homodimer."
J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]