Brevican (BCAN)

BEHAB; CSPG7; Chondroitin Sulfate Proteoglycan 7; Brevican Proteoglycan; Brevican core protein; Brain-enriched hyaluronan-binding protein

SPN	U667
HGNC	23059
MGI	1096385
PubMed	9117262
RGD	2194
UniProt	Q96GW7
Wiki	Brevican

Neurocan is a developmentally regulated CSPG that shares functional domains with the cartilage CSPG aggrecan and the fibroblast CSPG versican . Yamada et al. (1994) described the molecular cloning of a novel bovine brain proteoglycan of the aggrecan/versican/neurocan family. Since it is the shortest core protein in this family, they named it brevican (from the Latin word 'brevis,' meaning 'short').

A significant amount of brevican devoid of any glycosaminoglycan chains is present in brain, indicating that brevican is a 'part-time' proteoglycan. Northern blot analysis demonstrated that a single 3.3-kb brevican transcript is present predominantly in the brain and that it is expressed in primary cerebellar astrocytes but not in neurons.

Reference

"cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma."
Gene 256:139-147(2000) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]