V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ErbB3)

HER3; MDA-BF-1; C-ErbB3; LCCS2; ErbB3-S; P180-ErbB3; P45-SErbB3; P85-SErbB3; Receptor Tyrosine-Protein Kinase ErbB-3; Lethal Congenital Contracture Syndrome 2

SPN	U657
HGNC	3431
MGI	95411
PubMed	7515147
RGD	69323
UniProt	P21860
Wiki	ERBB3

Receptor tyrosine-protein kinase erbB-3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Reference

"Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors."
Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197(1989) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of an additional epidermal growth factor receptor-related gene."
Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909(1990) [PubMed] [Europe PMC] [Abstract]

"c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase."
Biochem. Biophys. Res. Commun. 192:1189-1197(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3."
J. Biol. Chem. 273:7717-7724(1998) [PubMed] [Europe PMC] [Abstract]

"Regulation of the ErbB3 binding protein Ebp1 by protein kinase C."
Mol. Cell. Endocrinol. 175:185-191(2001) [PubMed] [Europe PMC] [Abstract]

"Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein."
Mol. Cancer Res. 1:765-775(2003) [PubMed] [Europe PMC] [Abstract]

"Neuroglycan C, a novel member of the neuregulin family."
Biochem. Biophys. Res. Commun. 321:1045-1049(2004) [PubMed] [Europe PMC] [Abstract]

"Ebp1 isoforms distinctively regulate cell survival and differentiation."
Proc. Natl. Acad. Sci. U.S.A. 103:10917-10922(2006) [PubMed] [Europe PMC] [Abstract]

"Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway."
Am. J. Hum. Genet. 81:589-595(2007) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the extracellular region of HER3 reveals an interdomain tether."
Science 297:1330-1333(2002) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3."
Proc. Natl. Acad. Sci. U.S.A. 106:21608-21613(2009) [PubMed] [Europe PMC] [Abstract]

"ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 107:7692-7697(2010) [PubMed] [Europe PMC] [Abstract]

"Spatial structure and dimer-monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles."
Biochim. Biophys. Acta 1808:2081-2088(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]