G Protein Coupled Receptor Kinase 4 (GRK4)

GPRK2L; GPRK4; GRK4a; IT11; G protein-coupled receptor kinase GRK4

SPN	U651
HGNC	4543
MGI	95801
PubMed	11099476
RGD	61858
UniProt	P32298
Wiki	GRK4

G protein-coupled receptor kinase 4 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. G protein-coupled receptor kinases are a family of serine/threonine kinases that appear to play a role in receptor desensitization. Beta-adrenergic receptor kinase-1 and rhodopsin kinase are examples. They phosphorylate the activated form of the corresponding receptor, increasing its ability to interact with beta-arrestin or retinal arrestin, respectively. Binding of the arrestins to the receptors then blocks further activation of the respective signal transduction pathways.

Reference

"A novel G protein-coupled receptor kinase gene cloned from 4p16.3."
Hum. Mol. Genet. 1:697-703(1992) [PubMed] [Europe PMC] [Abstract]

"G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells."
J. Biol. Chem. 272:10188-10195(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants."
J. Biol. Chem. 271:6403-6410(1996) [PubMed] [Europe PMC] [Abstract]

"Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning."
Biochem. Biophys. Res. Commun. 199:848-854(1994) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression."
Hypertension 47:1131-1139(2006) [PubMed] [Europe PMC] [Abstract]

"G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."
J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]