Desmoglein 2 (DSG2)

ARVC10; ARVD10; CDHF5; HDGC; Cadherin family member 5

SPN	U642
HGNC	3049
MGI	1196466
PubMed	24166502
RGD	1311143
UniProt	Q14126
Wiki	Desmoglein_2

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18.

Desmoglein-2 is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.

Reference

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Submitted (OCT-2007) to the PDB data bank

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