Host Cell Factor C1 (HCFC1)

HCF-C1; CFF; HCF1; HCF1; HFC1; VCAF; VP16-Accessory Protein

SPN	U635
HGNC	4839
MGI	105942
PubMed	23539139
RGD	1563804
UniProt	P51610
Wiki	HCFC1

Host cell factor is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain.

The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Reference

"The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein."
Cell 74:115-125(1993) [PubMed] [Europe PMC] [Abstract]

"The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides."
J. Biol. Chem. 270:4387-4394(1995) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28."
Genomics 23:30-35(1994) [PubMed] [Europe PMC] [Abstract]

"Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): a potential role for proteolytic regulation of coactivator function."
Proc. Natl. Acad. Sci. U.S.A. 97:9425-9430(2000) [PubMed] [Europe PMC] [Abstract]

"The HCF repeat is an unusual proteolytic cleavage signal."
Genes Dev. 9:2445-2458(1995) [PubMed] [Europe PMC] [Abstract]

"Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor."
Mol. Cell. Biol. 17:5117-5126(1997) [PubMed] [Europe PMC] [Abstract]

"Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP."
Genes Dev. 11:3122-3127(1997) [PubMed] [Europe PMC] [Abstract]

"Nuclear localization of the C1 factor (host cell factor) in sensory neurons correlates with reactivation of herpes simplex virus from latency."
Proc. Natl. Acad. Sci. U.S.A. 96:1229-1233(1999) [PubMed] [Europe PMC] [Abstract]

"The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP."
EMBO J. 19:683-690(2000) [PubMed] [Europe PMC] [Abstract]

"Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency."
J. Virol. 74:934-943(2000) [PubMed] [Europe PMC] [Abstract]

"A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."
Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]

"Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP."
Mol. Cell. Biol. 20:919-928(2000) [PubMed] [Europe PMC] [Abstract]

"A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells."
Mol. Cell. Biol. 20:3568-3575(2000) [PubMed] [Europe PMC] [Abstract]

"Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16."
Nucleic Acids Res. 28:2446-2454(2000) [PubMed] [Europe PMC] [Abstract]

"N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif."
Proc. Natl. Acad. Sci. U.S.A. 97:10757-10762(2000) [PubMed] [Europe PMC] [Abstract]

"Interaction of HCF-1 with a cellular nuclear export factor."
J. Biol. Chem. 277:44292-44299(2002) [PubMed] [Europe PMC] [Abstract]

"Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1."
J. Biol. Chem. 277:46799-46808(2002) [PubMed] [Europe PMC] [Abstract]

"HCF-1 functions as a coactivator for the zinc finger protein Krox20."
J. Biol. Chem. 278:51116-51124(2003) [PubMed] [Europe PMC] [Abstract]

"Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."
Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]

"A protein sequestering system reveals control of cellular programs by the transcriptional coactivator HCF-1."
J. Biol. Chem. 279:33673-33683(2004) [PubMed] [Europe PMC] [Abstract]

"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."
Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]

"Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman."
J. Biol. Chem. 280:15257-15266(2005) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors."
Proc. Natl. Acad. Sci. U.S.A. 103:6817-6822(2006) [PubMed] [Europe PMC] [Abstract]

"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]

"The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection."
Proc. Natl. Acad. Sci. U.S.A. 104:10835-10840(2007) [PubMed] [Europe PMC] [Abstract]

"Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."
Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]

"Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."
Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation."
J. Biol. Chem. 284:7542-7552(2009) [PubMed] [Europe PMC] [Abstract]

"The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1."
J. Biol. Chem. 284:34179-34188(2009) [PubMed] [Europe PMC] [Abstract]

"Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1."
Mol. Cell. Biol. 29:2181-2192(2009) [PubMed] [Europe PMC] [Abstract]

"GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis."
Nature 459:455-459(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex."
J. Biol. Chem. 285:4268-4272(2010) [PubMed] [Europe PMC] [Abstract]

"The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway."
Proc. Natl. Acad. Sci. U.S.A. 108:2747-2752(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS."
EMBO J. 32:645-655(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"A noncoding, regulatory mutation implicates HCFC1 in nonsyndromic intellectual disability."
Am. J. Hum. Genet. 91:694-702(2012) [PubMed] [Europe PMC] [Abstract]