Vav 1 Oncogene (VAV1)

Proto Oncogene Vav; Vav 1 Guanine Nucleotide Exchange Factor

SPN	U631
HGNC	12657
MGI	98923
PubMed	14592821
RGD	3951
UniProt	P15498
Wiki	Vav1

Proto-oncogene vav is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Widely expressed in hematopoietic cells but not in other cell types.

This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Reference

"Mechanism of activation of the vav protooncogene."
Cell Growth Differ. 2:95-105(1991) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and regulation of the vav proto-oncogene."
Biochim. Biophys. Acta 1491:253-262(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential."
Mol. Cell. Biol. 11:1912-1920(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells."
EMBO J. 8:2283-2290(1989) [PubMed] [Europe PMC] [Abstract]

"The proline-rich region of Vav binds to Grb2 and Grb3-3."
Oncogene 11:1665-1669(1995) [PubMed] [Europe PMC] [Abstract]

"The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization."
Oncogene 7:611-618(1992) [PubMed] [Europe PMC] [Abstract]

"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product."
Immunity 5:591-604(1996) [PubMed] [Europe PMC] [Abstract]

"Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation."
Oncogene 15:2511-2520(1997) [PubMed] [Europe PMC] [Abstract]

"BLNK: a central linker protein in B cell activation."
Immunity 9:93-103(1998) [PubMed] [Europe PMC] [Abstract]

"hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways."
Mol. Cell. Biol. 19:3798-3807(1999) [PubMed] [Europe PMC] [Abstract]

"T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase."
Proc. Natl. Acad. Sci. U.S.A. 97:10923-10929(2000) [PubMed] [Europe PMC] [Abstract]

"DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."
Blood 100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]

"Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells."
Eur. J. Biochem. 269:3279-3288(2002) [PubMed] [Europe PMC] [Abstract]

"Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity."
Oncogene 21:7720-7729(2002) [PubMed] [Europe PMC] [Abstract]

"Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton."
J. Immunol. 174:1385-1392(2005) [PubMed] [Europe PMC] [Abstract]

"Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor."
Mol. Endocrinol. 19:939-949(2005) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Characterization of VIK-1: a new Vav-interacting Kruppel-like protein."
Oncogene 24:28-38(2005) [PubMed] [Europe PMC] [Abstract]

"A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation."
Biochem. J. 420:49-56(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the SH2 domain of human proto-oncogene protein VAV1."
Submitted (NOV-2005) to the PDB data bank