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Ring Finger Protein 4 (RNF4)

RES4-26; SNURF; E3 ubiquitin-protein ligase RNF4; Small nuclear ring finger protein

RING finger protein 4 contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.
The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U627Mu01 Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ring Finger Protein 4 (RNF4) Bioactivity
Antibodies NONE Monoclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ring Finger Protein 4 (RNF4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ring Finger Protein 4 (RNF4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ring Finger Protein 4 (RNF4) CLIA assay for Antigen Detection

Reference

"The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3."
DNA Res. 5:177-186(1998) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3."
Genomics 47:258-265(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor."
J. Biol. Chem. 275:7894-7901(2000) [PubMed] [Europe PMC] [Abstract]

"The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."
J. Biol. Chem. 278:38780-38785(2003) [PubMed] [Europe PMC] [Abstract]

"SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies."
Exp. Cell Res. 304:224-233(2005) [PubMed] [Europe PMC] [Abstract]

"RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation."
Nat. Cell Biol. 10:538-546(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"PARP-1 transcriptional activity is regulated by sumoylation upon heat shock."
EMBO J. 28:3534-3548(2009) [PubMed] [Europe PMC] [Abstract]

"Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3."
Mol. Cell. Biol. 29:3204-3218(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"The SUMO protease SENP6 is essential for inner kinetochore assembly."
J. Cell Biol. 188:681-692(2010) [PubMed] [Europe PMC] [Abstract]

"Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies."
Mol. Biol. Cell 21:4227-4239(2010) [PubMed] [Europe PMC] [Abstract]

"RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha."
Nucleic Acids Res. 38:1922-1931(2010) [PubMed] [Europe PMC] [Abstract]

"Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms."
PLoS ONE 7:E44949-E44949(2012) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the RING domain of the human RING finger protein 4."
Submitted (JUL-2007) to the PDB data bank