Protein Kinase B Alpha (PKBa)

AKT1; AKT; PKB-A; Proto-oncogene c-Akt; RAC-Alpha Serine/Threonine-Protein Kinase; V-akt Murine Thymoma Viral Oncogene Homolog 1

SPN	U614
HGNC	391
MGI	87986
PubMed	15047604
RGD	2081
UniProt	P31749
Wiki	PKB

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase.
In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

Reference

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Erratum
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Erratum
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"Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation."
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"CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site."
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"MOZ increases p53 acetylation and premature senescence through its complex formation with PML."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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"High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate."
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"Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change."
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"Discovery of pyrrolopyrimidine inhibitors of Akt."
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"Design of selective, ATP-competitive inhibitors of Akt."
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"Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition."
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"A transforming mutation in the pleckstrin homology domain of AKT1 in cancer."
Nature 448:439-444(2007) [PubMed] [Europe PMC] [Abstract]

"Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain."
Biochemistry 47:12260-12269(2008) [PubMed] [Europe PMC] [Abstract]

"A mosaic activating mutation in AKT1 associated with the Proteus syndrome."
N. Engl. J. Med. 365:611-619(2011) [PubMed] [Europe PMC] [Abstract]

"Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes."
Am. J. Hum. Genet. 92:76-80(2013) [PubMed] [Europe PMC] [Abstract]