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Profilin 1 (PFN1)

Epididymis tissue protein Li 184a

Profilin-1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.

Profilin is a ubiquitous 12- to 15-kD protein which inhibits the polymerization of actin. It is thought to function by complexing with unpolymerized actin in vivo. Dissociation of the profilin-actin complex is caused by binding of phosphatidylinositol 4,5-bisphosphate to profilin. Ampe et al. (1988) described the amino acid sequence of human platelet profilin and found it to have 95% homology to the sequence of calf spleen profilin.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Hu01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Hu01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Hu01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Hu01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Hu01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Mu01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Mu01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Mu01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Mu01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Mu01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Ra01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Ra01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Ra01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Ra01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Ra01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Ca01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Ca01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Ca01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Ca01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Ca01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Po01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Po01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Po01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Po01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Po01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Bo01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Bo01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Bo01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Bo01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Bo01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Rb01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Rb01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Rb01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Rb01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Rb01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU612Mo01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU612Mo01 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
PAU612Mo01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
Assay Kits CLU612Mo01 CLIA Kit for Profilin 1 (PFN1) CLIA assay for Antigen Detection
ELU612Mo01 ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis."
J. Biol. Chem. 263:5910-5915(1988) [PubMed] [Europe PMC] [Abstract]

"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence."
FEBS Lett. 228:17-21(1988) [PubMed] [Europe PMC] [Abstract]

"Distinct biochemical characteristics of the two human profilin isoforms."
Eur. J. Biochem. 229:621-628(1995) [PubMed] [Europe PMC] [Abstract]

"Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes."
EMBO J. 22:5928-5940(2003) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation."
Mol. Cell. Biol. 28:5196-5208(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern."
Biochemistry 32:13818-13829(1993) [PubMed] [Europe PMC] [Abstract]