Zyxin (ZYX)
ESP2; HED2
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Hu01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Hu01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Hu01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Hu01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Hu01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Mu01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Mu01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Mu01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Mu01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Mu01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Ra01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Ra01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Ra01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Ra01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Ra01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Ca01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Ca01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Ca01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Ca01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Ca01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Po01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Po01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Po01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Po01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Po01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Bo01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Bo01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Bo01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Bo01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Bo01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Rb01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Rb01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Rb01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Rb01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Rb01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU610Mo01 | Recombinant Zyxin (ZYX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU610Mo01 | Monoclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IP. |
| PAU610Mo01 | Polyclonal Antibody to Zyxin (ZYX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU610Mo01 | CLIA Kit for Zyxin (ZYX) | CLIA assay for Antigen Detection |
| ELU610Mo01 | ELISA Kit for Zyxin (ZYX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular characterization of human zyxin."
J. Biol. Chem. 271:31470-31478(1996) [PubMed] [Europe PMC] [Abstract]
"A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts."
Eur. J. Biochem. 241:657-663(1996) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
, Submitted (FEB-2008) to UniProtKB
"Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins."
J. Biol. Chem. 275:22503-22511(2000) [PubMed] [Europe PMC] [Abstract]
"Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation."
J. Virol. 75:11791-11802(2001) [PubMed] [Europe PMC] [Abstract]
"The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions."
J. Cell Biol. 161:33-39(2003) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
"Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding."
Mol. Cell 28:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]
"The LIM-domain protein zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo."
Dev. Dyn. 237:736-749(2008) [PubMed] [Europe PMC] [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]