Actinin Alpha 1 (ACTN1)
Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Alpha-actinin-1 is a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U609Hu01 | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| PU609Hu01 | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU609Hu | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Actinin Alpha 1 (ACTN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Actinin Alpha 1 (ACTN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Actinin Alpha 1 (ACTN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Actinin Alpha 1 (ACTN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Actinin Alpha 1 (ACTN1) | CLIA assay for Antigen Detection |
Reference
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Nucleic Acids Res. 17:6725-6725(1989) [PubMed] [Europe PMC] [Abstract]
"Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene."
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
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Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
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"The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase."
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"Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models."
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"ACTN1 mutations cause congenital macrothrombocytopenia."
Am. J. Hum. Genet. 92:431-438(2013) [PubMed] [Europe PMC] [Abstract]
"A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family."
PLoS ONE 8:E74728-E74728(2013) [PubMed] [Europe PMC] [Abstract]