Tight Junction Protein 1 (TJP1)

ZO1; Zona Occludens 1; Zona occludens protein 1; Zonula occludens protein 1

SPN	U583
HGNC	11827
MGI	98759
PubMed	8825647
RGD	1306305
UniProt	Q07157
Wiki	TJP1

Tight junction protein ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. Tight junction (zonula occludens) protein-1 (TJP1), also referred to as ZO-1, is a 200-kD protein located on a cytoplasmic membrane surface of vertebrate intercellular tight junctions. Willott et al. (1993) isolated a full-length cDNA sequence for human TJP1. Although the function of TJP1 is unknown, the cDNA sequence predicted a multi-domain signaling protein homologous to the product of the 'discs large-1' tumor suppressor gene of Drosophila  and several other membrane-associated proteins in mammals.

Reference

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"Comparative structural analysis of the erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity."
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"Domain swapping within PDZ2 is responsible for dimerization of ZO proteins."
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"Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites."
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"Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module."
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"Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration."
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"Solution structure of the second PDZ domain of Zonula Occludens 1."
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