Centromere Protein J (CENPJ)
LAP; LIP1; BM032; CPAP; MCPH6; Microcephaly,Primary Autosomal Recessive 6; Centrosomal P4.1-associated protein; LAG-3-associated protein; LYST-interacting protein 1
Centromere protein J is a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome.
This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Hu01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Hu01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Hu01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Hu01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Hu01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Mu01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Mu01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Mu01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Mu01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Mu01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Ra01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Ra01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Ra01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Ra01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Ra01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Ca01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Ca01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Ca01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Ca01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Ca01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Po01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Po01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Po01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Po01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Po01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Bo01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Bo01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Bo01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Bo01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Bo01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Rb01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Rb01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Rb01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Rb01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Rb01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU582Mo01 | Recombinant Centromere Protein J (CENPJ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU582Mo01 | Monoclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IP. |
| PAU582Mo01 | Polyclonal Antibody to Centromere Protein J (CENPJ) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU582Mo01 | CLIA Kit for Centromere Protein J (CENPJ) | CLIA assay for Antigen Detection |
| ELU582Mo01 | ELISA Kit for Centromere Protein J (CENPJ) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex."
Mol. Cell. Biol. 20:7813-7825(2000) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."
Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly."
Mol. Biol. Cell 15:2697-2706(2004) [PubMed] [Europe PMC] [Abstract]
"Plk4-induced centriole biogenesis in human cells."
Dev. Cell 13:190-202(2007) [PubMed] [Europe PMC] [Abstract]
"Role of CAP350 in centriolar tubule stability and centriole assembly."
PLoS ONE 3:E3855-E3855(2008) [PubMed] [Europe PMC] [Abstract]
"PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle."
EMBO J. 29:2395-2406(2010) [PubMed] [Europe PMC] [Abstract]
"Novel CENPJ mutation causes Seckel syndrome."
J. Med. Genet. 47:411-414(2010) [PubMed] [Europe PMC] [Abstract]
"Asterless is a scaffold for the onset of centriole assembly."
Nature 467:714-718(2010) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size."
Nat. Genet. 37:353-355(2005) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Genet. 37:555-555(2005)