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Small Heterodimer Partner (SHP)
Small Heterodimer Partner (SHP)
NR0B2; SHP1; Nuclear Receptor Subfamily 0,Group B,Member 2; Orphan nuclear receptor SHP
The small heterodimer partner (SHP) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR0B2 gene. SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain. Therefore technically it is neither a transcription factor nor nuclear receptor but nevertheless it is still classified as such due to relatively high sequence homology with other nuclear receptor family members.
The main function of SHP appears to be repression of other nuclear receptors through association to produce a non-productive heterodimer. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
U579Hu01
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
MU579Hu21
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
PU579Hu01
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
KEU579Hu
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
U579Ra01
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
PU579Ra01
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Small Heterodimer Partner (SHP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Small Heterodimer Partner (SHP) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Small Heterodimer Partner (SHP) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Small Heterodimer Partner (SHP) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Small Heterodimer Partner (SHP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Small Heterodimer Partner (SHP) CLIA assay for Antigen Detection
Reference
"An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors." Science 272:1336-1339(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Structure and expression of the orphan nuclear receptor SHP gene." J. Biol. Chem. 273:14398-14402(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects." Proc. Natl. Acad. Sci. U.S.A. 98:575-580(2001) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD." Mol. Endocrinol. 18:776-790(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP." Nat. Struct. Mol. Biol. 12:357-363(2005) [PubMed ] [Europe PMC ] [Abstract ]
"Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner." Mol. Cell. Biol. 31:1540-1550(2011) [PubMed ] [Europe PMC ] [Abstract ]
