Alpha-1,4-Galactosyltransferase (a4GALT)

A4GALT; P1; A14GALT; A4GALT1; PK; Lactosylceramide 4-Alpha-Galactosyltransferase; Globotriaosylceramide Synthase; Gb3 synthase; P1/Pk synthase; CD77 Synthase

SPN	U571
HGNC	18149
MGI	3512453
PubMed	20971946
RGD	621583
UniProt	Q9NPC4
Wiki	A4GALT

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.

The A4GALT gene encodes alpha-1,4-galactosyltransferase, an enzyme that transfers a galactose to the alpha-1,4 position of lactosylceramide to form globotriaosylceramide (GB3), also known as CD77. This glycolipid has been characterized on red blood cells as the P(k) antigen of the P blood group system.

Reference

"Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids."
J. Biol. Chem. 275:15152-15156(2000) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of the histo-blood group Pk UDP-galactose:Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase. Molecular genetic basis of the p phenotype."
J. Biol. Chem. 275:16723-16729(2000) [PubMed] [Europe PMC] [Abstract]

"Human-specific amino acid changes found in 103 protein-coding genes."
Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals."
J. Biol. Chem. 275:37752-37756(2000) [PubMed] [Europe PMC] [Abstract]

"Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype."
Transfusion 42:48-51(2002) [PubMed] [Europe PMC] [Abstract]