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Aminoacylase 1 (ACY1)

ACY1-D; ACY1D; ACYLASE; N-acyl-L-amino-acid amidohydrolase

Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids.

ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U569Hu01 Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies MU569Hu22 Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
PU569Hu01 Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits KEU569Hu ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aminoacylase 1 (ACY1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aminoacylase 1 (ACY1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aminoacylase 1 (ACY1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aminoacylase 1 (ACY1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aminoacylase 1 (ACY1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aminoacylase 1 (ACY1) CLIA assay for Antigen Detection

Reference

"The nucleotide sequence of human aminoacylase-1."
Biochim. Biophys. Acta 1174:201-203(1993) [PubMed] [Europe PMC] [Abstract]

"Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer."
J. Biol. Chem. 268:17010-17017(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family."
J. Biol. Chem. 278:44496-44504(2003) [PubMed] [Europe PMC] [Abstract]

"Aminoacylase I deficiency: a novel inborn error of metabolism."
Biochem. Biophys. Res. Commun. 338:1322-1326(2005) [PubMed] [Europe PMC] [Abstract]

"Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism."
Am. J. Hum. Genet. 78:401-409(2006) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Neurological findings in aminoacylase 1 deficiency."
Neurology 68:2151-2153(2007) [PubMed] [Europe PMC] [Abstract]

"The molecular basis of aminoacylase 1 deficiency."
Biochim. Biophys. Acta 1812:685-690(2011) [PubMed] [Europe PMC] [Abstract]