Actin Filament Associated Protein 1 (AFAP1)

AFAP-110; 110 kDa actin filament-associated protein

SPN	U562
HGNC	24017
MGI	1917542
PubMed	23333711
RGD	619959
UniProt	Q8N556
Wiki	AFAP1

Actin filament associated protein 1 is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.

Can cross-link actin filaments into both network and bundle structures By similarity. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

Reference

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"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells."
J. Cell. Physiol. 213:740-749(2007) [PubMed] [Europe PMC] [Abstract]

"AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts."
J. Clin. Invest. 117:2962-2973(2007) [PubMed] [Europe PMC] [Abstract]

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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]