Autocrine Motility Factor Receptor (AMFR)

GP78; RNF45; E3 ubiquitin-protein ligase AMFR; RING finger protein 45

SPN	U551
HGNC	463
MGI	1345634
PubMed	1655517
RGD	1311551
UniProt	Q9UKV5
Wiki	AMFR

Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. Autocrine motility factor receptor is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.

Specific receptor for the autocrine motility factor. Possesses ubiquitin ligase activity and can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome- mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems.

Reference

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor."
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"Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor."
J. Biol. Chem. 266:13442-13448(1991) [PubMed] [Europe PMC] [Abstract]

"The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum."
Proc. Natl. Acad. Sci. U.S.A. 98:14422-14427(2001) [PubMed] [Europe PMC] [Abstract]

"Overexpression of the tumor autocrine motility factor receptor, gp78, a ubiquitin protein ligase (E3), results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in Hep G2 cells."
J. Biol. Chem. 278:23984-23988(2003) [PubMed] [Europe PMC] [Abstract]

"Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase."
Mol. Cell 19:829-840(2005) [PubMed] [Europe PMC] [Abstract]

"Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane."
Proc. Natl. Acad. Sci. U.S.A. 102:14132-14138(2005) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases."
Arch. Biochem. Biophys. 483:66-74(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of RSGI RUH-076, a human CUE domain."
Submitted (SEP-2007) to the PDB data bank

"The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97."
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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]