Amine Oxidase, Copper Containing 3 (AOC3)

VAP1; HPAO; SSAO; Membrane primary amine oxidase; Vascular Adhesion Protein 1; Semicarbazide-Sensitive Amine Oxidase; Copper-Containing Amine Oxygen Oxidoreductase

SPN	U547
HGNC	550
MGI	1306797
PubMed	15664163
RGD	62058
UniProt	Q16853
Wiki	AOC3

SSAO can deaminate short-chain primary amines, but is insensitive to MAO inhibitors. Semicarbazide inhibits the enzyme, in addition to other hydrazines, hydroxylamine and propargylamine. However, hydrazines are weak inhibitors and stronger inhibitors have been developed.

SSAO is found in the smooth muscle of blood vessels and various other tissues. The physiological function of SSAO is not well understood. Development of blood vessels, lipolysis regulation, and detoxication are suggested. It may function as a scavenger enzyme to assist MAO. However, the oxidation process generates harmful products that may be involved in causing atherosclerosis and vascular damage in diabetes.

Reference

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Gene 179:279-286(1996) [PubMed] [Europe PMC] [Abstract]

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"Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina."
Gene 318:45-53(2003) [PubMed] [Europe PMC] [Abstract]

"Functional modulation of vascular adhesion protein-1 by a novel splice variant."
PLoS ONE 8:E54151-E54151(2013) [PubMed] [Europe PMC] [Abstract]

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Biochimie 89:916-925(2007) [PubMed] [Europe PMC] [Abstract]

"The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase."
Cell. Mol. Life Sci. 66:2743-2757(2009) [PubMed] [Europe PMC] [Abstract]

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