Activating Transcription Factor 3 (ATF3)
Cyclic AMP-dependent Transcription Factor ATF3
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors.
Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Hu01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Hu01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Hu01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Hu01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Hu01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Mu01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Mu01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Mu01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Mu01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Mu01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Ra01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Ra01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Ra01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Ra01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Ra01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Ca01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Ca01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Ca01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Ca01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Ca01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Po01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Po01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Po01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Po01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Po01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Bo01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Bo01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Bo01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Bo01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Bo01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Rb01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Rb01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Rb01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Rb01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Rb01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU542Mo01 | Recombinant Activating Transcription Factor 3 (ATF3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU542Mo01 | Monoclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IP. |
| PAU542Mo01 | Polyclonal Antibody to Activating Transcription Factor 3 (ATF3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU542Mo01 | CLIA Kit for Activating Transcription Factor 3 (ATF3) | CLIA assay for Antigen Detection |
| ELU542Mo01 | ELISA Kit for Activating Transcription Factor 3 (ATF3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms."
J. Biol. Chem. 269:15819-15826(1994) [PubMed] [Europe PMC] [Abstract]
"An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli."
Nucleic Acids Res. 30:2398-2406(2002) [PubMed] [Europe PMC] [Abstract]
"Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter."
J. Biol. Chem. 278:38402-38412(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
Erratum
Genes Dev. 4:682-682(1990)
"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]