Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7)

CHR-NA7; CHRN-A7; N-AChRA7; NAChRA7; N-AChR-A7; Neuronal Acetylcholine Receptor Alpha 7

SPN	U540
HGNC	1960
MGI	99779
PubMed	11803513
RGD	2348
UniProt	P36544
Wiki	CHRNA7

Neuronal acetylcholine receptor subunit alpha-7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.

Reference

"Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes."
Mol. Pharmacol. 45:546-554(1994) [PubMed] [Europe PMC] [Abstract]

"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequence of the human alpha-7 nicotinic acetylcholine receptor."
Drug Dev. Res. 30:252-256(1993)

"Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)."
Genomics 19:379-381(1994) [PubMed] [Europe PMC] [Abstract]

"A 3-Mb map of a large segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14."
Genomics 79:197-209(2002) [PubMed] [Europe PMC] [Abstract]

"Cluster analysis of an extensive human breast cancer cell line protein expression map database."
Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]

"Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."
J. Biol. Chem. 280:1257-1263(2005) [PubMed] [Europe PMC] [Abstract]

"RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]