Ancient Ubiquitous Protein 1 (AUP1)
Ancient ubiquitous protein 1 is a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes.
The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. AUP1 in lipid droplets, and perhaps at the ER, has a role in ubiquitin-mediated protein degradation by recruiting UBE2G2.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Hu01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Hu01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Hu01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Hu01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Hu01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Mu01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Mu01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Mu01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Mu01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Mu01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Ra01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Ra01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Ra01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Ra01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Ra01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Ca01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Ca01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Ca01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Ca01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Ca01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Po01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Po01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Po01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Po01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Po01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Bo01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Bo01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Bo01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Bo01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Bo01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Rb01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Rb01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Rb01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Rb01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Rb01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU538Mo01 | Recombinant Ancient Ubiquitous Protein 1 (AUP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU538Mo01 | Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IP. |
PAU538Mo01 | Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLU538Mo01 | CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) | CLIA assay for Antigen Detection |
ELU538Mo01 | ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3."
J. Biol. Chem. 277:28934-28941(2002) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins."
Proc. Natl. Acad. Sci. U.S.A. 105:12325-12330(2008) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"Solution structure of RSGI RUH-075, a human CUE domain."
Submitted (SEP-2007) to the PDB data bank