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Ancient Ubiquitous Protein 1 (AUP1)

Ancient ubiquitous protein 1 is a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes.

The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. AUP1 in lipid droplets, and perhaps at the ER, has a role in ubiquitin-mediated protein degradation by recruiting UBE2G2.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Hu01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Hu01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Hu01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Hu01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Hu01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Mu01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Mu01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Mu01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Mu01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Mu01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Ra01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Ra01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Ra01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Ra01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Ra01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Ca01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Ca01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Ca01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Ca01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Ca01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Po01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Po01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Po01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Po01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Po01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Bo01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Bo01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Bo01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Bo01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Bo01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Rb01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Rb01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Rb01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Rb01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Rb01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU538Mo01 Recombinant Ancient Ubiquitous Protein 1 (AUP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU538Mo01 Monoclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IP.
PAU538Mo01 Polyclonal Antibody to Ancient Ubiquitous Protein 1 (AUP1) WB; IHC; ICC; IF.
Assay Kits CLU538Mo01 CLIA Kit for Ancient Ubiquitous Protein 1 (AUP1) CLIA assay for Antigen Detection
ELU538Mo01 ELISA Kit for Ancient Ubiquitous Protein 1 (AUP1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3."
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Submitted (SEP-2007) to the PDB data bank