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Aurora Kinase C (AURKC)

AIE2; AIK3; AurC; STK13; ARK-3; Aurora-C; Serine/Threonine-Protein Kinase 13; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase aurora-C

Serine/threonine-protein kinase 13 is a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.mouse Aie1 (Aurora/Ipl1/EG2-1) and human STK13, which they designated AIE2. Both Aie1 and AIE2 contain a central serine/threonine kinase domain. The authors reported that AIE2 contains 309 amino acids. Northern blot analysis detected expression of a 1.35-kb AIE2 mRNA only in testis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U537Hu01 Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
PU537Hu01 Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U537Mu01 Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
PU537Mu01 Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U537Ra01 Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
PU537Ra01 Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aurora Kinase C (AURKC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aurora Kinase C (AURKC) Bioactivity
Antibodies NONE Monoclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aurora Kinase C (AURKC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aurora Kinase C (AURKC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aurora Kinase C (AURKC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aurora Kinase C (AURKC) CLIA assay for Antigen Detection

Reference

"Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators."
DNA Cell Biol. 17:823-833(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter."
Genomics 53:406-409(1998) [PubMed] [Europe PMC] [Abstract]

"Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3."
J. Biol. Chem. 274:7334-7340(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel human Aurora C splicing variant."
Biochem. Biophys. Res. Commun. 328:353-361(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells."
Cell Motil. Cytoskeleton 59:249-263(2004) [PubMed] [Europe PMC] [Abstract]

"Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C."
J. Biol. Chem. 279:47201-47211(2004) [PubMed] [Europe PMC] [Abstract]

"Aurora C is directly associated with Survivin and required for cytokinesis."
Genes Cells 10:617-626(2005) [PubMed] [Europe PMC] [Abstract]

"Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility."
Nat. Genet. 39:661-665(2007) [PubMed] [Europe PMC] [Abstract]

"Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein."
Biochem. Biophys. Res. Commun. 408:647-653(2011) [PubMed] [Europe PMC] [Abstract]

"A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development."
Hum. Reprod. 26:1868-1881(2011) [PubMed] [Europe PMC] [Abstract]

"A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis."
Mol. Hum. Reprod. 17:762-768(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]