Adenomatosis Polyposis Coli Protein (APC)

DP2; DP2.5; DP3; FAP; FPC; GS; Deleted in polyposis 2.5

SPN	U531
HGNC	583
MGI	88039
PubMed	11283619
RGD	2123
UniProt	P25054
Wiki	APC

APC (adenomatosis polyposis coli) is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor. The APC protein helps control how often a cell divides, how it attaches to other cells within a tissue, or whether a cell moves within or away from a tissue. This protein also helps ensure that the chromosome number in cells produced through cell division is correct. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. The activity of one protein in particular, beta-catenin, is controlled by the APC protein.

Reference

"Identification of deletion mutations and three new genes at the familial polyposis locus."
Cell 66:601-613(1991) [PubMed] [Europe PMC] [Abstract]

"Identification of FAP locus genes from chromosome 5q21."
Science 253:661-665(1991) [PubMed] [Europe PMC] [Abstract]

"Asef, a link between the tumor suppressor APC and G-protein signaling."
Science 289:1194-1197(2000) [PubMed] [Europe PMC] [Abstract]

"Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer."
Cancer Res. 52:643-645(1992) [PubMed] [Europe PMC] [Abstract]

"Association of the APC tumor suppressor protein with catenins."
Science 262:1734-1737(1993) [PubMed] [Europe PMC] [Abstract]

"Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene."
Am. J. Hum. Genet. 59:1193-1201(1996) [PubMed] [Europe PMC] [Abstract]

"Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein."
Science 272:1020-1023(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein."
Oncogene 14:2425-2433(1997) [PubMed] [Europe PMC] [Abstract]

"A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor."
Clin. Genet. 57:205-212(2000) [PubMed] [Europe PMC] [Abstract]

"Human APC2 localization and allelic imbalance."
Cancer Res. 61:7978-7984(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of functional domains of human EB1 family proteins."
J. Biol. Chem. 278:49721-49731(2003) [PubMed] [Europe PMC] [Abstract]

"Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin."
J. Biol. Chem. 279:49188-49198(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli."
Genes Cells 11:453-464(2006) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42."
Oncogene 26:7620-7627(2007) [PubMed] [Europe PMC] [Abstract]

"Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains."
Genes Dev. 22:528-542(2008) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"An EB1-binding motif acts as a microtubule tip localization signal."
Cell 138:366-376(2009) [PubMed] [Europe PMC] [Abstract]

"The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."
EMBO Rep. 10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]

"Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration."
Oncogene 28:1357-1365(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."
Proc. Natl. Acad. Sci. U.S.A. 107:18517-18522(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1)."
J. Biol. Chem. 286:19204-19214(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning."
J. Biol. Chem. 287:1734-1741(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor."
J. Mol. Biol. 301:147-156(2000) [PubMed] [Europe PMC] [Abstract]

"Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex."
EMBO J. 20:6203-6212(2001) [PubMed] [Europe PMC] [Abstract]

"Structural basis of the axin-adenomatous polyposis coli interaction."
EMBO J. 19:2270-2279(2000) [PubMed] [Europe PMC] [Abstract]

"Mutations of the APC (adenomatous polyposis coli) gene."
Hum. Mutat. 2:425-434(1993) [PubMed] [Europe PMC] [Abstract]

"Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain."
Biochemistry 49:5143-5153(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility."
Biochem. Biophys. Res. Commun. 412:732-736(2011) [PubMed] [Europe PMC] [Abstract]

"Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients."
Science 253:665-669(1991) [PubMed] [Europe PMC] [Abstract]

"Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene."
Hum. Mol. Genet. 1:229-233(1992) [PubMed] [Europe PMC] [Abstract]

"Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma."
Hum. Mol. Genet. 1:559-563(1992) [PubMed] [Europe PMC] [Abstract]

"Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients."
Hum. Mutat. 1:467-473(1992) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene."
Eur. J. Cancer 30A:1709-1713(1994) [PubMed] [Europe PMC] [Abstract]

"Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients."
Hum. Mol. Genet. 3:1687-1688(1994) [PubMed] [Europe PMC] [Abstract]

Erratum
Hum. Mol. Genet. 3:1918-1918(1994)

"The molecular basis of Turcot's syndrome."
N. Engl. J. Med. 332:839-847(1995) [PubMed] [Europe PMC] [Abstract]

"Somatic mutations of the APC gene in sporadic hepatoblastomas."
Cancer Res. 56:3320-3323(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis."
Hum. Mutat. 9:7-16(1997) [PubMed] [Europe PMC] [Abstract]

"Drastic genetic instability of tumors and normal tissues in Turcot syndrome."
Oncogene 15:2877-2881(1997) [PubMed] [Europe PMC] [Abstract]

"The APC I1307K allele and breast cancer risk."
Nat. Genet. 20:13-14(1998) [PubMed] [Europe PMC] [Abstract]

"The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history."
Proc. Natl. Acad. Sci. U.S.A. 95:10722-10727(1998) [PubMed] [Europe PMC] [Abstract]

"The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews."
Nat. Genet. 20:62-65(1998) [PubMed] [Europe PMC] [Abstract]

"Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism."
Am. J. Hum. Genet. 64:378-384(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition."
J. Med. Genet. 36:14-20(1999) [PubMed] [Europe PMC] [Abstract]

"The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis."
Nat. Med. 5:1071-1075(1999) [PubMed] [Europe PMC] [Abstract]

"APC mutations in sporadic medulloblastomas."
Am. J. Pathol. 156:433-437(2000) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]