B-Cell CLL/Lymphoma 10 (Bcl10)

CARMEN; CIPER; CLAP; c-E10; mE10; CARD-containing molecule enhancing NF-kappa-B; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN

SPN	U519
HGNC	989
MGI	1337994
PubMed	10319863
RGD	620544
UniProt	O95999
Wiki	BCL10

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. B-cell lymphoma/leukemia 10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Reference

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Cell 96:35-45(1999) [PubMed] [Europe PMC] [Abstract]

"CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10."
J. Biol. Chem. 274:9955-9961(1999) [PubMed] [Europe PMC] [Abstract]

"Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase."
J. Biol. Chem. 274:9962-9968(1999) [PubMed] [Europe PMC] [Abstract]

"mE10, a novel caspase recruitment domain-containing proapoptotic molecule."
J. Biol. Chem. 274:10287-10292(1999) [PubMed] [Europe PMC] [Abstract]

"CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis."
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"c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB."
J. Biol. Chem. 274:20127-20132(1999) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 104:908-913(2007) [PubMed] [Europe PMC] [Abstract]

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