Breakpoint Cluster Region (BCR)

ALL; BCR/FGFR1; BCR1; CML; FGFR1/BCR; PHL; Renal carcinoma antigen NY-REN-26

SPN	U517
HGNC	1014
MGI	88141
PubMed	2487142
RGD	1307993
UniProt	P11274
Wiki	BCR_gene

The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Reference

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Oncogene 2:113-117(1988) [PubMed] [Europe PMC] [Abstract]

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Erratum
Proc. Natl. Acad. Sci. U.S.A. 84:2507-2507(1987)

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Nature 315:758-761(1985) [PubMed] [Europe PMC] [Abstract]

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Nucleic Acids Res. 18:7119-7125(1990) [PubMed] [Europe PMC] [Abstract]

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Nature 330:386-388(1987) [PubMed] [Europe PMC] [Abstract]

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"Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript."
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Mol. Cell. Biol. 11:1854-1860(1991) [PubMed] [Europe PMC] [Abstract]

"Bcr encodes a GTPase-activating protein for p21rac."
Nature 351:400-402(1991) [PubMed] [Europe PMC] [Abstract]

"BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner."
Cell 66:161-171(1991) [PubMed] [Europe PMC] [Abstract]

"The BCR gene encodes a novel serine/threonine kinase activity within a single exon."
Cell 67:459-468(1991) [PubMed] [Europe PMC] [Abstract]

"The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr."
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"src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP."
J. Biol. Chem. 289:35397-35408(2014) [PubMed] [Europe PMC] [Abstract]

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Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]