C-Src Tyrosine Kinase (CSK)

C-Src kinase; Tyrosine-protein kinase CSK; Protein-tyrosine kinase CYL

SPN	U499
HGNC	2444
MGI	88537
PubMed	22499769
RGD	1308800
UniProt	P41240
Wiki	CSK

C-src tyrosine kinase includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. This protein specifically phosphorylates Tyr-504 residue on human leukocyte-specific protein tyrosine kinase, which acts as a negative regulatory site. It may also act on the LYN and FYN kinases.

CSK downregulates tyrosine kinase activity of the SRC oncoprotein through tyrosine phosphorylation of the SRC carboxy terminus. Since cell transformation by SRC oncoproteins is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene .

Reference

"CYL encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src)."
Oncogene 6:2013-2018(1991) [PubMed] [Europe PMC] [Abstract]

"Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase."
Proc. Natl. Acad. Sci. U.S.A. 88:10411-10415(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases."
Gene 110:205-211(1992) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human CSK locus."
Oncogene 8:1365-1369(1993) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity."
EMBO J. 11:2919-2924(1992) [PubMed] [Europe PMC] [Abstract]

"Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s)."
Oncogene 8:1241-1247(1993) [PubMed] [Europe PMC] [Abstract]

"Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system."
Arch. Biochem. Biophys. 345:135-142(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure."
Biochem. J. 322:927-935(1997) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn."
FEBS Lett. 474:179-183(2000) [PubMed] [Europe PMC] [Abstract]

"Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation."
J. Exp. Med. 191:1591-1604(2000) [PubMed] [Europe PMC] [Abstract]

"Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)."
Eur. J. Immunol. 31:1825-1836(2001) [PubMed] [Europe PMC] [Abstract]

"Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor."
J. Exp. Med. 193:497-507(2001) [PubMed] [Europe PMC] [Abstract]

"LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling."
J. Exp. Med. 198:1453-1462(2003) [PubMed] [Europe PMC] [Abstract]

"A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis."
Am. J. Hum. Genet. 75:330-337(2004) [PubMed] [Europe PMC] [Abstract]

"C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases."
Growth Factors 23:233-244(2005) [PubMed] [Europe PMC] [Abstract]

"p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity."
EMBO J. 26:2843-2855(2007) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"The tyrosine kinase Csk dimerizes through Its SH3 domain."
PLoS ONE 4:E7683-E7683(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"RhoH modulates pre-TCR and TCR signalling by regulating LCK."
Cell. Signal. 23:249-258(2011) [PubMed] [Europe PMC] [Abstract]

"SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop."
FEBS Lett. 341:79-85(1994) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]