Calcium Dependent Secretion Activator (CADPS)
CAPS; CAPS1; Calcium-dependent activator protein for secretion 1
CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2 -regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.
Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Hu01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Hu01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Hu01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Hu01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Hu01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Mu01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Mu01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Mu01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Mu01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Mu01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Ra01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Ra01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Ra01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Ra01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Ra01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Ca01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Ca01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Ca01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Ca01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Ca01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Po01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Po01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Po01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Po01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Po01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Bo01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Bo01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Bo01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Bo01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Bo01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Rb01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Rb01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Rb01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Rb01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Rb01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU494Mo01 | Recombinant Calcium Dependent Secretion Activator (CADPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU494Mo01 | Monoclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IP. |
| PAU494Mo01 | Polyclonal Antibody to Calcium Dependent Secretion Activator (CADPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU494Mo01 | CLIA Kit for Calcium Dependent Secretion Activator (CADPS) | CLIA assay for Antigen Detection |
| ELU494Mo01 | ELISA Kit for Calcium Dependent Secretion Activator (CADPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family."
Genomics 81:279-291(2003) [PubMed] [Europe PMC] [Abstract]
"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis."
J. Biol. Chem. 272:19637-19640(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."
Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)."
Submitted (NOV-2004) to the PDB data bank