Calcium Modulating Ligand (CAMLG)

CAML; Calcium Signal-Modulating Cyclophilin Ligand; Calcium-Signal Modulating Cyclophilin Ligand; Cyclophilin B-Binding Protein

SPN	U492
HGNC	1471
MGI	104728
PubMed	8824814
RGD	69297
UniProt	P49069
Wiki	CAMLG

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.

Calcium signal-modulating cyclophilin ligand functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

Reference

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