Calcium Activated Nucleotidase 1 (CANT1)

SCAN1; SHAPY; CAN1; Soluble Ca-Activated Nucleotidase,Isozyme 1; Apyrase homolog; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107

SPN	U491
HGNC	19721
MGI	1923275
PubMed	21435463
RGD	628743
UniProt	Q8WVQ1
Wiki	CANT1

It has long been known that the salivary glands of hematophagous (blood-feeding) arthropods secrete soluble apyrases, which are potent nucleotide hydrolyzing enzymes capable of hydrolyzing extracellular ATP and ADP, the latter being a major agonist contributing to platelet aggregation. Only recently, however, has the identification of proteins homologous to these apyrases been reported in non-blood-feeding organisms such as rodents and humans.

SCAN-1 is the homologue of soluble apyrases found in blood-sucking insects. This family of nucleotidases is unrelated in sequence to more well-studied nucleotidases, and very little is known about the enzymatic mechanism. By multiple sequence alignment, eight regions that are highly conserved in the hSCAN-1 family were identified and named.

Reference

"Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases."
Arch. Biochem. Biophys. 406:105-115(2002) [PubMed] [Europe PMC] [Abstract]

"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning, expression, and functional characterization of a Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase."
J. Biol. Chem. 277:36978-36986(2002) [PubMed] [Europe PMC] [Abstract]

"Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change."
Biochemistry 43:9185-9194(2004) [PubMed] [Europe PMC] [Abstract]

"Mutation of CANT1 causes Desbuquois dysplasia."
Am. J. Med. Genet. A 152:1157-1160(2010) [PubMed] [Europe PMC] [Abstract]

"Further delineation of CANT1 phenotypic spectrum and demonstration of its role in proteoglycan synthesis."
Hum. Mutat. 33:1261-1266(2012) [PubMed] [Europe PMC] [Abstract]

"Structure and protein design of a human platelet function inhibitor."
Cell 116:649-659(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of CANT1 mutations in Desbuquois dysplasia."
Am. J. Hum. Genet. 85:706-710(2009) [PubMed] [Europe PMC] [Abstract]

"Desbuquois dysplasia type I and fetal hydrops due to novel mutations in the CANT1 gene."
Eur. J. Hum. Genet. 19:1133-1137(2011) [PubMed] [Europe PMC] [Abstract]

"A founder mutation of CANT1 common in Korean and Japanese Desbuquois dysplasia."
J. Hum. Genet. 56:398-400(2011) [PubMed] [Europe PMC] [Abstract]

"CANT1 mutation is also responsible for Desbuquois dysplasia, type 2 and Kim variant."
J. Med. Genet. 48:32-37(2011) [PubMed] [Europe PMC] [Abstract]