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Calpain 2, Large Subunit (CAPN2)

CANPL2; CANPml; mCANP; Calpain-2 Catalytic Subunit; Calcium-activated neutral proteinase 2; Calpain M-type; Calpain large polypeptide L2; Millimolar-calpain

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit.
This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.Two transcript variants encoding different isoforms have been found for this gene. Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U490Hu01 Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies MU490Hu21 Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
PU490Hu01 Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits KEU490Hu ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 2, Large Subunit (CAPN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 2, Large Subunit (CAPN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 2, Large Subunit (CAPN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 2, Large Subunit (CAPN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 2, Large Subunit (CAPN2) CLIA assay for Antigen Detection

Reference

"Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease."
Biochemistry 27:8122-8128(1988) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease."
J. Biol. Chem. 264:6404-6411(1989) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease."
J. Biol. Chem. 282:27810-27824(2007) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium."
Proc. Natl. Acad. Sci. U.S.A. 97:588-592(2000) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]