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Core Binding Factor Beta Subunit (CBFb)

CBF-B; PEBP2B; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit

is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis and osteogenesis . The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U487Hu01 Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
PU487Hu01 Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U487Mu01 Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
PU487Mu01 Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Core Binding Factor Beta Subunit (CBFb) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Core Binding Factor Beta Subunit (CBFb) Bioactivity
Antibodies NONE Monoclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Core Binding Factor Beta Subunit (CBFb) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Core Binding Factor Beta Subunit (CBFb) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Core Binding Factor Beta Subunit (CBFb) CLIA assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the leukemia-associated human CBFB gene."
Genomics 26:571-579(1995) [PubMed] [Europe PMC] [Abstract]

Erratum
Genomics 38:107-107(1996) [PubMed] [Europe PMC] [Abstract]

"Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia."
Science 261:1041-1044(1993) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta."
EMBO J. 19:3004-3015(2000) [PubMed] [Europe PMC] [Abstract]

"The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp."
Nat. Struct. Biol. 8:371-378(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta."
Nat. Struct. Biol. 6:620-623(1999) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]