Chromobox Homolog 3 (CBX3)

HECH; HP1-GAMMA; HP1Hs-Gamma; HP1 Gamma Homolog,Drosophila; Heterochromatin protein 1 homolog gamma; Modifier 2 protein

SPN	U485
HGNC	1553
MGI	108515
PubMed	22684280
UniProt	Q13185
Wiki	CBX3

Chromobox protein homolog 3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Reference

"Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1."
J. Biol. Chem. 271:14653-14656(1996) [PubMed] [Europe PMC] [Abstract]

"Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1."
FEBS Lett. 467:17-21(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB

"Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR."
J. Biol. Chem. 272:14983-14989(1997) [PubMed] [Europe PMC] [Abstract]

"INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1."
J. Cell Biol. 143:1763-1774(1998) [PubMed] [Europe PMC] [Abstract]

"Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment."
Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998) [PubMed] [Europe PMC] [Abstract]

"Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells."
Chromosoma 108:220-234(1999) [PubMed] [Europe PMC] [Abstract]

"KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing."
Mol. Cell. Biol. 19:4366-4378(1999) [PubMed] [Europe PMC] [Abstract]

"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins."
Nature 410:116-120(2001) [PubMed] [Europe PMC] [Abstract]

"A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells."
Science 296:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]

"A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1."
Nat. Cell Biol. 6:1135-1141(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."
Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]

"ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1."
J. Biol. Chem. 285:18-29(2010) [PubMed] [Europe PMC] [Abstract]

"Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."
Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the complex of chromobox homolog 3 (CBX3) [Homo sapiens] and peptide."
Submitted (FEB-2009) to the PDB data bank